PI(s): Adelman, Zach N (Project Leader)

Investigators: Carpenetti, Tiffany L (Investigator)

Abstract: Studies of Aedes aegypti have shown that heat shock stress affects the susceptibility of the mosquitoes to arboviruses. These studies have included testing whole organism susceptibility and cell culture studies. Stress response can be induced not only by heat but also by chemicals and viral infection. It is not known whether the induction of heat shock proteins helps viral proliferation by folding packaging proteins or if it takes a defensive role against the virus. Understanding the induction of heat shock protein expression may lead to a better understanding of the interaction between stress response and viral infection in disease vector mosquitoes.